GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs10935120 | 1 | rs6769885 | chr3:134286913 | CEP63 | chr3:134204575-134293852:+ | 0.31 | 6.72 | 5.18E-11 | Height |
| THCA | cis | rs9847710 | 1 | rs6770152 | chr3:53100214 | NT5DC2 | chr3:52558386-52569093:- | 0.16 | 3.58 | 0.000379 | Ulcerative colitis |
| THCA | cis | rs7968440 | 1 | rs67701624 | chr12:50928938 | DIP2B | chr12:50898768-51142448:+ | 0.12 | 3.82 | 0.000151 | Fibrinogen |
| THCA | cis | rs9876781 | 1 | rs6770470 | chr3:48435123 | ATRIP | chr3:48488141-48507708:+ | 0.17 | 3.78 | 0.000176 | Longevity |
| THCA | cis | rs9876781 | 1 | rs6770470 | chr3:48435123 | TREX1 | chr3:48501186-48509043:+ | -0.24 | -5.66 | 2.59E-8 | Longevity |
| THCA | cis | rs9858542 | 1 | rs6770670 | chr3:49686682 | MST1 | chr3:49721381-49726196:- | 0.13 | 3.88 | 0.000117 | Crohn's disease;Ulcerative colitis |
| THCA | cis | rs1124376 | 1 | rs6771941 | chr3:20157077 | EFHB | chr3:19920968-19988501:- | 0.21 | 3.4 | 0.000722 | Bipolar disorder and schizophrenia |
| THCA | cis | rs2070488 | 1 | rs6772046 | chr3:38479660 | ACVR2B | chr3:38495790-38534631:+ | 0.13 | 3.39 | 0.000763 | Electrocardiographic conduction measures |
| THCA | cis | rs2070488 | 1 | rs6772046 | chr3:38479660 | LOC100128640 | chr3:38492524-38496311:- | 0.24 | 5.12 | 4.34E-7 | Electrocardiographic conduction measures |
| THCA | cis | rs2070488 | 1 | rs6772046 | chr3:38479660 | XYLB | chr3:38388251-38456467:+ | 0.2 | 4.89 | 1.38E-6 | Electrocardiographic conduction measures |
| THCA | cis | rs1552244 | 1 | rs6772315 | chr3:10113644 | C3orf10 | chr3:10157333-10168873:+ | -0.21 | -4.34 | 1.71E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs6772315 | chr3:10113644 | VHL | chr3:10183319-10193744:+ | -0.2 | -4.51 | 8.09E-6 | Alzheimer's disease |
| THCA | cis | rs73201462 | 1 | rs6772407 | chr3:128044372 | EEFSEC | chr3:127872313-128127488:+ | -0.19 | -3.44 | 0.000634 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs7631605 | 1 | rs6772548 | chr3:37075934 | EPM2AIP1 | chr3:37027358-37034795:- | 0.13 | 3.88 | 0.000118 | Cerebrospinal P-tau181p levels |
| THCA | cis | rs7631605 | 1 | rs6772548 | chr3:37075934 | LRRFIP2 | chr3:37094117-37217851:- | 0.51 | 14.09 | 6.12E-38 | Cerebrospinal P-tau181p levels |